Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li></ol> false 理化学研究所ゲノム医科学研究センター・RIKEN ENU-base gene-driven mutagenesisで作製。Mount Sinai Hospital・Tatiana Lipina、John Roderらにより育成。C57BL/6へN15世代以上戻し交配された（C57BL/6JとC57BL/6NCrlの混合背景）。 RIKEN GSC RIKEN GSC RBRC06365 Homozygote x Homozygote Homozygote x Homozygote Mouse Models for Human Disease 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Neuron, 54, 387-402 (2007).<br>営利機関の利用者は、別途寄託者に連絡する。<br>非営利機関の利用者は、本件リソースを利用して研究過程において得られた発明及び成果物について特許申請及び第三者と使用料ライセンス契約を行う場合、利用者は事前に理研ＢＲＣに連絡の上、両者で、発明者、所有権、特許出願、ライセンス料等の取扱いについて、実施に先立って協議するものとする。 DISC1 RGSC1393 - DISC1-Q31L, B6-Disc1/1393 DISC1 RGSC1393 - DISC1-Q31L, B6-Disc1/1393 Disc1遺伝子のENUミュータント。Disc1遺伝子変異 (L100P) を有するマウスは統合失調症様の行動を示し、もう1つのDisc1遺伝子変異 (Q31L) を有するマウスはうつ病様の行動を示す。統合失調症様の行動=100P/100P、100P/+、100P/31L。うつ病様の行動=31L/31L。正常=31L/+、+/+。Disc1<Rgsc1390> (L100P) (RBRC06364) 、Disc1<Rgsc1393> (Q31L) (RBRC06365) 。 In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Neuron, 54, 387-402 (2007).The RECIPIENT of for-profit institution must contact the DEPOSITOR separately.<br>The RECIPIENT of not for-profit institution must contact and discuss in good faith with the DEPOSITOR regarding inventorship, ownership, patent filing and licese fees and others, prior to filing a patent or make a contract with license fees with a third party for invention or products obtained from research results by using the BIOLOGICAL RESOURCES. DISC1 has been reported as a responsible gene for mental illness which was originally found in a large Scottish family with major mental illness such as depression and schizophrenia. Two independently derived ENU-induced mutant mice which have missense mutations in exon 2 of Disc1 gene were developed and analyzed jointly by RIKEN (Japan), University of Edinburgh (UK), and Mount Sinai Hospital (Canada). The mutant mouse with Q31L (Disc1<Rgsc1393>) showed depressive-like behavior with defects, e.g., in the forced swim test. The other mutant mouse with L100P (Disc1<Rgsc1390>) exhibited schizophrenic-like behavior, with profound defect in prepulse inhibition and latent inhibition. These Disc1 missense mutant mice are expected to be very useful as models for depression and schizophrenia. Disc1<Rgsc1390> (L100P)(RBRC06364), Disc1<Rgsc1393> (Q31L)(RBRC06365). B6(D2)-Disc1<Rgsc1393>/Rod B6(D2)-Disc1<Rgsc1393>/Rod Originated from RIKEN ENU-base gene-driven mutagenesis. Established the B6 congenic strains by Tatiana Lipina and John Roder, Mount Sinai Hospital. The mutant mice were backcrossed to C57BL/6 over 15 times (C57BL/6J and C57BL/6NCrl mixed). C（3〜6か月） C (3-6 months)